Explore about alleles
For partners who want to know about alleles which exist in Database of Genomic Variants for Vietnamese Population, we present alleles page. Currently we categorize the alleles types:
- HLA Allele
- PGx Star Allele
Maybe some of you do not familiar with the term HLA or PGx, here is the brief description:
HLA Allele#
The human leukocyte antigen (HLA) system (the major histocompatibility complex [MHC] in humans) is an important part of the immune system and is controlled by genes located on chromosome 6. It encodes cell surface molecules specialized to present antigenic peptides to the T-cell receptor (TCR) on T cells.
MHC molecules that present antigen (Ag) are divided into 2 main classes:
- Class I MHC molecules
- Class II MHC molecules
In our page, we provide three filtering methods for HLA alleles, via classes, genes or allele frequency. Partners can get information about how allele frequencies distributed globally or refer to the allele report by clicking on embed link in the data table.
For more information about HLA genes, please refer to this page for details.
PGx Star Allele#
PGx stands for Pharmacogenomics - is the study of how genes affect a person’s response to drugs. This relatively new field combines pharmacology (the science of drugs) and genomics (the study of genes and their functions) to develop effective, safe medications and doses that will be tailored to a person’s genetic makeup.
Many drugs that are currently available are “one size fits all,” but they don't work the same way for everyone. It can be difficult to predict who will benefit from a medication, who will not respond at all, and who will experience negative side effects (called adverse drug reactions). Adverse drug reactions are a significant cause of hospitalizations and deaths in the United States. With the knowledge gained from the Human Genome Project, researchers are learning how inherited differences in genes affect the body’s response to medications.
Currently PGxs Allele can be filtered by class or gene.
Note: Very Important Pharmacogene class (VIP) summaries provide an overview of a significant gene involved in metabolism of, or response to, one or several drugs. Often, VIPs either play a role in the metabolism of many drugs (e.g. CYP2D6), or contain variants which potentially contribute to a severe drug response (e.g. HLA-B). VIP summaries typically include background information on the gene including any disease associations, as well as in-depth information on the gene’s pharmacogenetics. Many VIP summaries have been published in the journal Pharmacogenetics and Genomics.